Billie Moore came to the Cal State Fullerton campus in 1969 as the new head coach of the women's basketball team. She was only 26 years old, and this would be her first time at the helm of a college program.

Federal Title IX legislation mandating increased opportunities for women in athletics would not be signed by President Nixon until 1972, but Cal State Fullerton was already ahead of many colleges and universities by sponsoring women's basketball. UCLA would not field a women's basketball team until 1974 and they would be followed by USC in 1976. College women's basketball was initially governed by the CIAW and AIAW before the NCAA eventually began folding in those programs in 1981.

1969-70 went off with a bang as the Billie Moore-led team went 17-1 and the season was highlighted by an invitation to the 16-team CIAW national championship tournament held on the campus of Northeastern University in Boston, Massachusetts. The Titans knocked off three teams before ultimately defeating West Chester State College (Pennsylvania) 50-46 in the championship final. The Titans were CIAW national champions in year one.

Moore, described as a hard-nosed teacher of basketball fundamentals, would go on to an eye-popping 140-15 (.903) record in her eight seasons at Fullerton. The Titans finished as conference winners in all eight of those seasons and would go on to the CIAW or AIAW national championship tournaments in seven of those seasons, finishing in third place in 1972 and 1975.

The 1973-77 teams would feature All-American and Titan Hall of Famer, Nancy Dunkle. Dunkle finished her four-year Titan career with 1,519 points and would average 9.2 rebounds in 82 games. Dunkle would go on to be selected to several of the Team USA women's basketball teams.

While at Cal State Fullerton, Moore was an assistant coach for the USA women's national team for the Pan American Games and World University Games. In 1976 the Summer Olympics added women's basketball. Billie Moore was selected to be the first USA Olympics women's basketball head coach in history. The team that she chose would include Titan Nancy Dunkle, and some of the soon-to-be historic names in women's basketball history. Among them were Nancy Lieberman, Ann Meyers, and Pat Head (Summitt). Team USA would be awarded the silver medal in Montreal, Canada.

Following the 1976-77 season, Moore accepted an offer to be head coach at UCLA. She would be replaced by the just-graduated Nancy Dunkle. Like at Fullerton, Moore had immediate success at UCLA, winning the 1977-78 AIAW national championship with the Bruins. She would retire from UCLA and end her coaching career in 1993. Billie Moore was selected to the Naismith Memorial Basketball Hall of Fame, and Women's Basketball Hall of Fame in 1999.